The Stanley Neuropathology Consortium Integrative Database

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Purpose of this integrative database

Provide a user friendly tool for exploring and mining the Stanley Neuropathology datasets
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Identify reliable biomarkers for schizophrenia and bipolar disorder
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Identify molecular mechanisms underlying major mental disorder related traits such as cytoarchitectural abnormalities, and neurotransmitter deficits.
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Assist in the identification of novel targets, or to verify existing targets, for drugs for schizophrenia, bipolar disorder, and depression.

The Stanley Neuropathology Consortium Integrative Database is a web-based tool that integrates SMRI data sets and analysis software.

Data sets used in the SNCID

Integrative analysis module
- 6161 neuropathology datasets
- 23 gene expression microarray datasets
- RNA-Seq datasets from hippocampus
- Individually genotyped SNP data
Downloading raw data
- Raw data using array collection (105 cases) is now available to download
- RNA-Seq datasets from 7 brain tissues of three Stanley tissue collections are available to download.

Citation

About The Stanley Neuropathology Consortium

The Neuropathology Consortium is a collection of 60 brains, consisting of 15 each diagnosed with schizophrenia, bipolar disorder, or major depression, and unaffected controls. The four groups are matched by age, sex, race, postmortem interval, pH, side of brain, and mRNA quality as summarized in the Demographic Details Chart.

Coded specimens are sent to researchers with the code varying from researcher to researcher to ensure that all studies are blinded. The code is released to the researcher only when the data have been collected and submitted to SMRI.

Further information about tissue availability, conditions for tissue use and how to request tissue is available of the SMRI homepage.